Article
Molecular imprint of exposure to naturally occurring genetic variants of human cytomegalovirus on the T cell repertoire.
Scientific reports - 10 Feb 2014
Smith Corey, Gras Stephanie, Brennan Rebekah M, Bird Nicola L, Valkenburg Sophie A, Twist Kelly-Anne, Burrows Jacqueline M, Miles John J, Chambers Daniel, Bell Scott, Campbell Scott, Kedzierska Katherine, Burrows Scott R, Rossjohn Jamie, Khanna Rajiv
Abstract excerpt
Exposure to naturally occurring variants of herpesviruses in clinical settings can have a dramatic impact on anti-viral immunity. Here we have evaluated the molecular imprint of variant peptide-MHC complexes on the T-cell repertoire during human cytomegalovirus (CMV) infection and demonstrate that primary co-infection with genetic variants of CMV was coincident with development of strain-specific T-cell immunity...
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