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Broadly targeted human cytomegalovirus-specific CD4 <b>+</b> and CD8 <b>+</b> T cells dominate the memory compartments of exposed subjects

5 Sept 2005

Abstract excerpt

Human cytomegalovirus (HCMV) infections of immunocompetent hosts are characterized by a dynamic, life-long interaction in which host immune responses, particularly of T cells, restrain viral replication and prevent disease but do not eliminate the virus or preclude transmission. Because HCMV is among the largest and most complex of known viruses, the T cell resources committed to maintaining this balance have...

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PMID: 16147978
DOI: 10.1084/jem.20050882

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