Article
Genotype frequency and F ST analysis of polymorphisms in immunoregulatory genes in Chinese and Caucasian populations.
Immunogenetics - 1 Nov 2007
Lan Qing, Shen Min, Garcia-Rossi Dino, Chanock Stephen, Zheng Tongzhang, Berndt Sonja I, Puri Vinita, Li Guilan, He Xingzhou, Welch Robert, Zahm Shelia H, Zhang Luoping, Zhang Yawei, Smith Martyn, Wang Sophia S, Chiu Brian C-H, Linet Martha, Hayes Richard, Rothman Nathaniel, Yeager Meredith
Abstract excerpt
Selection and genetic drift can create genetic differences between populations. Cytokines and chemokines play an important role in both hematopoietic development and the inflammatory response. We compared the genotype frequencies of 45 SNPs in 30 cytokine and chemokine genes in two healthy Chinese populations and one Caucasian population. Several SNPs in IL4 had substantial genetic differentiation between the...
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