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Article

Cardiac malformations in Pdgfralpha mutant embryos are associated with increased expression of WT1 and Nkx2.5 in the second heart field.

Developmental dynamics : an official publication of the American Association of Anatomists - 1 Aug 2010

Bax Noortje A M, Bleyl Steven B, Gallini Radiosa, Wisse Lambertus J, Hunter Jennifer, Van Oorschot Angelique A M, Mahtab Edris A F, Lie-Venema Heleen, Goumans Marie-Jose, Betsholtz Christer, Gittenberger-de Groot Adriana C

Abstract excerpt

Platelet-derived growth factor receptor alpha (Pdgfralpha) identifies cardiac progenitor cells in the posterior part of the second heart field. We aim to elucidate the role of Pdgfralpha in this region. Hearts of Pdgfralpha-deficient mouse embryos (E9.5-E14.5) showed cardiac malformations consist...

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Share to Embryo, Mammalian
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Heart Defects, Congenital

Share to Homeobox Protein Nkx-2.5

Share to Homeodomain Proteins

Share to Receptor, Platelet-Derived Growth Factor alpha

Share to WT1 Proteins

Source

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Identifiers

PMID: 20658695
DOI: 10.1002/dvdy.22363
PMCID: PMC2911638

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20658695-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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