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Article

Optimizing the detection of lung cancer patients harboring anaplastic lymphoma kinase (ALK) gene rearrangements potentially suitable for ALK inhibitor treatment.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Nov 2010

Camidge D Ross, Kono Scott A, Flacco Antonella, Tan Aik-Choon, Doebele Robert C, Zhou Qing, Crino Lucio, Franklin Wilbur A, Varella-Garcia Marileila

Abstract excerpt

PURPOSE: Anaplastic lymphoma kinase (ALK) rearrangements, associated with sensitivity to an experimental ALK/MET inhibitor, occur in 3% to 5% of non-small cell lung cancers. Intratumoral fluorescence in situ hybridization (FISH) heterogeneity has been reported. We explored the heterogeneity basis, the requirements for accurately determining ALK FISH positivity, and the effect of enriching the tested population...

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Source

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Identifiers

PMID: 21062932
DOI: 10.1158/1078-0432.CCR-10-0851
PMCID: PMC3395226

Genes

ALK
EGFR
MET
KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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