Article
Investigating the influence of KIBRA and CLSTN2 genetic polymorphisms on cross-sectional and longitudinal measures of memory performance and hippocampal volume in older individuals.
Neuropsychologia - 1 Nov 2015
Boraxbekk C J, Ames David, Kochan Nicole A, Lee Teresa, Thalamuthu Anbupalam, Wen Wei, Armstrong Nicola J, Kwok John B J, Schofield Peter R, Reppermund Simone, Wright Margaret J, Trollor Julian N, Brodaty Henry, Sachdev Perminder, Mather Karen A
Abstract excerpt
The variability of episodic memory decline and hippocampal atrophy observed with increasing age may partly be explained by genetic factors. KIBRA (kidney and brain expressed protein) and CLSTN2 (calsyntenin 2) are two candidate genes previously linked to episodic memory performance and volume of the hippocampus, a key memory structure. However, whether polymorphisms in these two genes also influence age-related...
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