Article
WWC1 genotype modulates age-related decline in episodic memory function across the adult life span.
Biological psychiatry - 1 May 2014
Muse John, Emery Matthew, Sambataro Fabio, Lemaitre Herve, Tan Hao-Yang, Chen Qiang, Kolachana Bhaskar S, Das Saumitra, Callicott Joseph H, Weinberger Daniel R, Mattay Venkata S
Abstract excerpt
BACKGROUND: Episodic memory (EM) declines with age and the rate of decline is variable across individuals. A single nucleotide polymorphism (rs17070145) in the WWC1 gene that encodes the KIBRA protein critical for long-term potentiation and memory consolidation has previously been associated with EM performance, as well as differences in hippocampal engagement during EM tasks using functional magnetic resonance...
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