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Article

KIBRA is associated with accelerated cognitive decline and hippocampal atrophy in APOE ε4-positive cognitively normal adults with high Aβ-amyloid burden.

Scientific reports - 1 Feb 2018

Porter Tenielle, Burnham Samantha C, Doré Vincent, Savage Greg, Bourgeat Pierrick, Begemann Kimberly, Milicic Lidija, Ames David, Bush Ashley I, Maruff Paul, Masters Colin L, Rowe Christopher C, Rainey-Smith Stephanie, Martins Ralph N, Groth David, Verdile Giuseppe, Villemagne Victor L, Laws Simon M

Abstract excerpt

A single nucleotide polymorphism, rs17070145, in the KIdney and BRAin expressed protein (KIBRA) gene has been associated with cognition and hippocampal volume in cognitively normal (CN) individuals. However, the impact of rs17070145 on longitudinal cognitive decline and hippocampal atrophy in CN adults at greatest risk of developing Alzheimer's disease is unknown. We investigated the impact rs17070145 has on the...

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Source

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Identifiers

PMID: 29391469
DOI: 10.1038/s41598-018-20513-y
PMCID: PMC5794989

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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