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Mislocalisation of Activated Receptor Tyrosine Kinases - Challenges for Cancer Therapy.

Trends in molecular medicine - 1 Sept 2020

Schmidt-Arras Dirk, Böhmer Frank-D

Abstract excerpt

Activating mutations in genes encoding receptor tyrosine kinases (RTKs) mediate proliferation, cell migration, and cell survival, and are therefore important drivers of oncogenesis. Numerous targeted cancer therapies are directed against activated RTKs, including small compound inhibitors, and immunotherapies. It has recently been discovered that not only certain RTK fusion proteins, but also many full-length...

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PMID: 32593582
DOI: 10.1016/j.molmed.2020.06.002

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