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Article

ER residential chaperone GRP78 unconventionally relocalizes to the cell surface via endosomal transport.

Cellular and molecular life sciences : CMLS - 1 Jun 2021

Van Krieken Richard, Tsai Yuan-Li, Carlos Anthony J, Ha Dat P, Lee Amy S

Abstract excerpt

Despite new advances on the functions of ER chaperones at the cell surface, the translocation mechanisms whereby these chaperones can escape from the ER to the cell surface are just emerging. Previously we reported that in many cancer types, upon ER stress, IRE1α binds to and triggers SRC activation resulting in KDEL receptor dispersion from the Golgi and suppression of retrograde transport. In this study, using...

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Share to Cell Membrane
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Endoplasmic Reticulum

Share to Endoplasmic Reticulum Chaperone BiP

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Share to Heat-Shock Proteins

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Source

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Identifiers

PMID: 33974094
DOI: 10.1007/s00018-021-03849-z
PMCID: PMC8254793

Genes

BET1
DNAJC3
SRC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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