Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Met endosomal signalling: in the right place, at the right time.

The international journal of biochemistry & cell biology - 1 Apr 2014

Barrow-McGee Rachel, Kermorgant Stéphanie

Abstract excerpt

Deregulated signalling of the Receptor Tyrosine Kinase (RTK), Met, and/or its ligand HGF have been associated with cancer formation and progression to metastasis, with Met/HGF often overexpressed or mutated. Thus, Met has become a major target for cancer therapy and its inhibition is currently being tested in the clinic. It has recently become evident that, instead of signalling at the plasma membrane only, Met...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Transformation, Neoplastic
Share to Endocytosis
Share to Endosomes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to HGF gene

Share to Models, Biological

Share to Mutation

Share to Proto-Oncogene Proteins c-met

Share to Signal Transduction

Source

Identifiers

PMID: 24440758
DOI: 10.1016/j.biocel.2014.01.009

Genes

HGF
STAT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Met endosomal signalling: in the right place, at the right time.PMID 24440758Read ↗

A direct role for Met endocytosis in tumorigenesis.Semantic proximity Read ↗

LC3C-Mediated Autophagy Selectively Regulates the Met RTK and HGF-Stimulated Migration and InvasionSemantic proximity Read ↗

Met Receptor: A Moving TargetSemantic proximity Read ↗

EGF receptor trafficking: consequences for signaling and cancer.Semantic proximity Read ↗

Spatiotemporal regulation of the hepatocyte growth factor receptor MET activity by sorting nexins 1/2 in HCT116 colorectal cancer cellsSemantic proximity Read ↗

Targeting Cellular Trafficking of Fibroblast Growth Factor Receptors as a Strategy for Selective Cancer TreatmentSemantic proximity Read ↗

Interplay of autophagy, receptor tyrosine kinase signalling and endocytic traffickingSemantic proximity Read ↗

Mutant p53 enhances MET trafficking and signalling to drive cell scattering and invasion.Semantic proximity Read ↗

Endocytosis and cancer.Semantic proximity Read ↗

The MET Oncogene Network of Interacting Cell Surface ProteinsSemantic proximity Read ↗

The Endosomal Recycling Pathway—At the Crossroads of the CellSemantic proximity Read ↗

Met/Hepatocyte growth factor receptor ubiquitination suppresses transformation and is required for Hrs phosphorylation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.