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Article

Genetic correlations of psychiatric traits with body composition and glycemic traits are sex- and age-dependent.

Nature communications - 18 Dec 2019

Hübel Christopher, Gaspar Héléna A, Coleman Jonathan R I, Hanscombe Ken B, Purves Kirstin, Prokopenko Inga, Graff Mariaelisa, Ngwa Julius S, Workalemahu Tsegaselassie, O'Reilly Paul F, Bulik Cynthia M, Breen Gerome

Abstract excerpt

Body composition is often altered in psychiatric disorders. Using genome-wide common genetic variation data, we calculate sex-specific genetic correlations amongst body fat %, fat mass, fat-free mass, physical activity, glycemic traits and 17 psychiatric traits (up to N = 217,568). Two patterns emerge: (1) anorexia nervosa, schizophrenia, obsessive-compulsive disorder, and education years are negatively...

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Identifiers

PMID: 31852892
DOI: 10.1038/s41467-019-13544-0
PMCID: PMC6920448

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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