Article
IL-37 Confers Protection against Mycobacterial Infection Involving Suppressing Inflammation and Modulating T Cell Activation.
PloS one - 1 Jan 2017
Liu Haipeng, Zheng Ruijuan, Wang Peng, Yang Hua, He Xin, Ji Qun, Bai Wenjuan, Chen Hao, Chen Jianxia, Peng Wenxia, Liu Siyu, Liu Zhonghua, Ge Baoxue
Abstract excerpt
Interleukin-37 (IL-37), a novel member of the IL-1 family, plays fundamental immunosuppressive roles by broadly reducing both innate inflammation and acquired immunity, but whether it is involved in the pathogenesis of tuberculosis (TB) has not been clearly elucidated. In this study, single nucleotide polymorphism (SNP) analysis demonstrated an association of the genetic variant rs3811047 of IL-37 with TB...
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