Article
Quantifying the fitness cost of HIV-1 drug resistance mutations through phylodynamics.
PLoS pathogens - 1 Feb 2018
Kühnert Denise, Kouyos Roger, Shirreff George, Pečerska Jūlija, Scherrer Alexandra U, Böni Jürg, Yerly Sabine, Klimkait Thomas, Aubert Vincent, Günthard Huldrych F, Stadler Tanja, Bonhoeffer Sebastian
Abstract excerpt
Drug resistant HIV is a major threat to the long-term efficacy of antiretroviral treatment. Around 10% of ART-naïve patients in Europe are infected with drug-resistant HIV type 1. Hence it is important to understand the dynamics of transmitted drug resistance evolution. Thanks to routinely performed drug resistance tests, HIV sequence data is increasingly available and can be used to reconstruct the phylogenetic...
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