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Article

Identification of pharmacogenetic predictors of lipid-lowering response to atorvastatin in Chilean subjects with hypercholesterolemia.

Clinica chimica acta; international journal of clinical chemistry - 18 Feb 2012

Rosales Alexy, Alvear Marysol, Cuevas Alejandro, Saavedra Nicolás, Zambrano Tomás, Salazar Luis A

Abstract excerpt

BACKGROUND: Statins are normally the first-line therapy for hypercholesterolemia (HC); however, the lipid-lowering response shows high interindividual variation. We investigated the effect of four polymorphisms in CYP3A4, CYP3A5 and ABCB1 genes on response to atorvastatin and CYP3A4 activity in Chilean subjects with HC. METHODS: A total of 142 hypercholesterolemic individuals underwent atorvastatin therapy...

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Source

Identifiers

PMID: 22120734
DOI: 10.1016/j.cca.2011.11.003

Genes

ABCB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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