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Genetic Analysis of Hepatitis C Virus with Defective Genome and Its Infectivity in Vitro

16 Apr 2009

Abstract excerpt

Replication and infectivity of hepatitis C virus (HCV) with a defective genome is ambiguous. We molecularly cloned 38 HCV isolates with defective genomes from 18 patient sera. The structural regions were widely deleted, with the 5' untranslated, core, and NS3-NS5B regions preserved. All of the deletions were in frame, indicating that they are translatable to the authentic terminus. Phylogenetic analyses showed...

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PMID: 19369330
DOI: 10.1128/jvi.02674-08

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