Article
Enhanced replication contributes to enrichment of hepatitis B virus with a deletion in the core gene.
Virology - 1 Aug 2000
Günther S, Piwon N, Jung A, Iwanska A, Schmitz H, Will H
Abstract excerpt
Accumulation in immunosuppressed patients of hepatitis B virus (HBV) with a deletion in the C gene is associated with severe liver disease. The aim of this study was to determine the phenotype of such genomes in vitro. Four C gene fragments with different types of deletions were inserted in the c...
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