Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Caspase-1 is required for maintenance of marginal zone B cells in pristane-induced lupus.

Lupus - 1 Jan 2016

Morse M D, Clark K L, Cascalho M, Kahlenberg J M

Abstract excerpt

OBJECTIVE: Caspase-1 is required for nephritis and robust autoantibody development in the pristane model of murine lupus. The objective of this study was to evaluate the immune response and to study the splenic B and T cell populations in wild-type (WT) and caspase-1-/- mice following pristane injection in order to develop an understanding of why absence of caspase-1 is protective in pristane-induced lupus....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antibodies, Antinuclear
Share to Caspase 1
Share to Immunization

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Immunoglobulin M

Share to Nitrophenols

Share to Ovalbumin

Share to Phenylacetates

Share to Terpenes

Source

Open in PubMed Open full text

Identifiers

PMID: 26405027
DOI: 10.1177/0961203315606982
PMCID: PMC4679614

Genes

TLR7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Caspase-1 is required for maintenance of marginal zone B cells in pristane-induced lupus.PMID 26405027Read ↗

TLR9 Deficiency Leads to Accelerated Renal Disease and Myeloid Lineage Abnormalities in Pristane-Induced Murine LupusSemantic proximity Read ↗

Immune cell alterations in a pristane‐induced lupus model in C57BL/6J miceSemantic proximity Read ↗

Deficiency of type I IFN receptor in lupus-prone New Zealand mixed 2328 mice decreases dendritic cell numbers and activation and protects from disease.Semantic proximity Read ↗

Sustained NPSLE-like phenotype in the absence of systemic lupus-like disease in TLR7-deficient B6.Nba2 mice.Semantic proximity Read ↗

Pristane-induced granulocyte recruitment promotes phenotypic conversion of macrophages and protects against diffuse pulmonary hemorrhage in Mac-1 deficiency.Semantic proximity Read ↗

Macrophage Migration Inhibitory Factor deficiency attenuates kidney Injury by downregulating cytokines via CYR61 in lupus-prone mice induced by pristane.Semantic proximity Read ↗

Fas and Fas ligand mutations inhibit autoantibody production in pristane-induced lupus.Semantic proximity Read ↗

IRF4 deficiency abrogates lupus nephritis despite enhancing systemic cytokine production.Semantic proximity Read ↗

Early, transient depletion of plasmacytoid dendritic cells ameliorates autoimmunity in a lupus modelSemantic proximity Read ↗

Structure and function of renal macrophages and dendritic cells from lupus-prone mice.Semantic proximity Read ↗

Induced murine models of systemic lupus erythematosus.Semantic proximity Read ↗

B cell subsets in pristane-induced autoimmunity.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.