Risk of non-Hodgkin lymphoma associated with germline variation in genes that regulate the cell cycle, apoptosis, and lymphocyte development.

doi:10.1158/1055-9965.EPI-08-1037

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Article

Risk of non-Hodgkin lymphoma associated with germline variation in genes that regulate the cell cycle, apoptosis, and lymphocyte development.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Apr 2009

Morton Lindsay M, Purdue Mark P, Zheng Tongzhang, Wang Sophia S, Armstrong Bruce, Zhang Yawei, Menashe Idan, Chatterjee Nilanjan, Davis Scott, Lan Qing, Vajdic Claire M, Severson Richard K, Holford Theodore R, Kricker Anne, Cerhan James R, Leaderer Brian, Grulich Andrew, Yeager Meredith, Cozen Wendy, Hoar Zahm Shelia, Chanock Stephen J, Rothman Nathaniel, Hartge Patricia

Abstract excerpt

Chromosomal translocations are the hallmark genetic aberration in non-Hodgkin lymphoma (NHL), with specific translocations often selectively associated with specific NHL subtypes. Because many NHL-associated translocations involve cell cycle, apoptosis, and lymphocyte development regulatory genes, we evaluated NHL risk associated with common genetic variation in 20 candidate genes in these pathways. Genotyping of...

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PMID: 19336552
DOI: 10.1158/1055-9965.EPI-08-1037
PMCID: PMC2716008

Genes

BCL6
CCND1
MYC

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