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Article

Secondary structure and membrane topology of dengue virus NS4B N-terminal 125 amino acids.

Biochimica et biophysica acta - 1 Dec 2015

Li Yan, Kim Young Mee, Zou Jing, Wang Qing-Yin, Gayen Shovanlal, Wong Ying Lei, Lee Le Tian, Xie Xuping, Huang Qiwei, Lescar Julien, Shi Pei-Yong, Kang CongBao

Abstract excerpt

The transmembrane NS4B protein of dengue virus (DENV) is a validated antiviral target that plays important roles in viral replication and invasion of innate immune response. The first 125 amino acids of DENV NS4B are sufficient for inhibition of alpha/beta interferon signaling. Resistance mutations to NS4B inhibitors are all mapped to the first 125 amino acids. In this study, we expressed and purified a protein...

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Source

Identifiers

PMID: 26403837
DOI: 10.1016/j.bbamem.2015.09.016

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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