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Article

The C-terminal helical domain of dengue virus precursor membrane protein is involved in virus assembly and entry.

Virology - 5 Feb 2011

Hsieh Szu-Chia, Zou Gang, Tsai Wen-Yang, Qing Min, Chang Gwong-Jen, Shi Pei-Yong, Wang Wei-Kung

Abstract excerpt

The role of the α-helical domain (MH) of dengue virus (DENV) precursor membrane protein in replication was investigated by site-directed mutagenesis. Proline substitutions of three residues (120, 123 and 127) at the C-terminus, but not those at the N-terminus of MH domain, reduced the virus-like particles of DENV1, DENV2 and DENV4 detected in supernatants. In a DENV2 replicon trans-packaging system, these three...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21129763
DOI: 10.1016/j.virol.2010.11.006
PMCID: PMC3100346

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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