Article
A Second RNA-Binding Site in the NS1 Protein of Influenza B Virus.
Structure (London, England : 1993) - 6 Sept 2016
Ma Li-Chung, Guan Rongjin, Hamilton Keith, Aramini James M, Mao Lei, Wang Shanshan, Krug Robert M, Montelione Gaetano T
Abstract excerpt
Influenza viruses cause a highly contagious respiratory disease in humans. The NS1 proteins of influenza A and B viruses (NS1A and NS1B proteins, respectively) are composed of two domains, a dimeric N-terminal domain and a C-terminal domain, connected by a flexible polypeptide linker. Here we report the 2.0-Å X-ray crystal structure and nuclear magnetic resonance studies of the NS1B C-terminal domain, which...
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