Theoretical investigations on the effects of mutations in important residues of NS1B on its RNA-binding using molecular dynamics simulations.

Abstract excerpt

NS1B protein plays an important role in countering host antiviral defense and virulence of influenza virus B, considered as the promising target. The first experimental structure of the NS1B protein has recently been determined, was able to bind to double-stranded RNA (dsRNA). However, few studies attempt to investigate the RNA-binding mechanism of the NS1B. In this study, we provide our understanding of the...

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