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Article

Reduced brain volumes in mice expressing APP-Austrian mutation but not in mice expressing APP-Swedish-Austrian mutations.

Neuroscience letters - 12 Dec 2008

Van Broeck Bianca, Vanhoutte Greet, Cuijt Ivy, Pereson Sandra, Joris Geert, Timmermans Jean-Pierre, Van der Linden Annemie, Van Broeckhoven Christine, Kumar-Singh Samir

Abstract excerpt

We previously described two transgenic mouse lines expressing sub-endogenous levels of the 'Austrian' APP-T714I mutation (driven by the prenatally active PDGF-beta promoter; APP-Au mice) and showing intraneuronal Abeta pathology and reduced brain volumes on MRI at 12 and 20 months of age. To furt...

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Identifiers

PMID: 18840503
DOI: 10.1016/j.neulet.2008.09.073

Genes

APP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18840503-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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