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Article

Frequent IGF2/H19 domain epigenetic alterations and elevated IGF2 expression in epithelial ovarian cancer.

Molecular cancer research : MCR - 1 Apr 2006

Murphy Susan K, Huang Zhiqing, Wen Yaqing, Spillman Monique A, Whitaker Regina S, Simel Lauren R, Nichols Teresa D, Marks Jeffrey R, Berchuck Andrew

Abstract excerpt

Overexpression of the imprinted insulin-like growth factor-II (IGF2) is a prominent characteristic of gynecologic malignancies. The purpose of this study was to determine whether IGF2 loss of imprinting (LOI), aberrant H19 expression, and/or epigenetic deregulation of the IGF2/H19 imprinted domain contributes to elevated IGF2 expression in serous epithelial ovarian tumors. IGF2 LOI was observed in 5 of 23...

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Source

Identifiers

PMID: 16603642
DOI: 10.1158/1541-7786.MCR-05-0138

Genes

IGF2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Frequent IGF2/H19 domain epigenetic alterations and elevated IGF2 expression in epithelial ovarian cancer.PMID 16603642Read ↗

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