Article
IGF2 promotes growth of adrenocortical carcinoma cells, but its overexpression does not modify phenotypic and molecular features of adrenocortical carcinoma.
PloS one - 1 Jan 2014
Guillaud-Bataille Marine, Ragazzon Bruno, de Reyniès Aurélien, Chevalier Claire, Francillard Isabelle, Barreau Olivia, Steunou Virginie, Guillemot Johann, Tissier Frédérique, Rizk-Rabin Marthe, René-Corail Fernande, Al Ghuzlan Abir, Assié Guillaume, Bertagna Xavier, Baudin Eric, Le Bouc Yves, Bertherat Jérôme, Clauser Eric
Abstract excerpt
Insulin-like growth factor 2 (IGF2) overexpression is an important molecular marker of adrenocortical carcinoma (ACC), which is a rare but devastating endocrine cancer. It is not clear whether IGF2 overexpression modifies the biology and growth of this cancer, thus more studies are required before IGF2 can be considered as a major therapeutic target. We compared the phenotypical, clinical, biological, and...
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