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Article

LRH-1 drives colon cancer cell growth by repressing the expression of the CDKN1A gene in a p53-dependent manner.

Nucleic acids research - 29 Jan 2016

Kramer Holly B, Lai Chun-Fui, Patel Hetal, Periyasamy Manikandan, Lin Meng-Lay, Feller Stephan M, Fuller-Pace Frances V, Meek David W, Ali Simak, Buluwela Laki

Abstract excerpt

Liver receptor homologue 1 (LRH-1) is an orphan nuclear receptor that has been implicated in the progression of breast, pancreatic and colorectal cancer (CRC). To determine mechanisms underlying growth promotion by LRH-1 in CRC, we undertook global expression profiling following siRNA-mediated LRH-1 knockdown in HCT116 cells, which require LRH-1 for growth and in HT29 cells, in which LRH-1 does not regulate...

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Identifiers

PMID: 26400164
DOI: 10.1093/nar/gkv948
PMCID: PMC4737183

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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