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Article

Reversible infertility in a liver receptor homologue-1 (LRH-1)-knockdown mouse model.

Reproduction, fertility, and development - 1 Jan 2014

Gerrits Han, Paradé Marc C B C, Koonen-Reemst Annemie M C B, Bakker Nicole E C, Timmer-Hellings Lenita, Sollewijn Gelpke Maarten D, Gossen Jan A

Abstract excerpt

Liver receptor homologue-1 (LRH-1) is an orphan nuclear receptor that has been implicated in steroid hormone biosynthesis and fertility. Herein we describe a transgenic inducible short hairpin (sh) RNA mouse model that was used to study the effect of transient LRH-1 knockdown in vivo. Induction of expression of the shRNA directed against LRH-1 for 2-6 weeks resulted in 80% knockdown of LRH-1 protein in the ovary...

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Identifiers

PMID: 23425349
DOI: 10.1071/RD12131

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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