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11β-Hydroxysteroid dehydrogenases and the brain: From zero to hero, a decade of progress

8 Dec 2010

Abstract excerpt

Glucocorticoids have profound effects on brain development and adult CNS function. Excess or insufficient glucocorticoids cause myriad abnormalities from development to ageing. The actions of glucocorticoids within cells are determined not only by blood steroid levels and target cell receptor density, but also by intracellular metabolism by 11β-hydroxysteroid dehydrogenases (11β-HSD). 11β-HSD1 regenerates active...

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PMID: 21144857
DOI: 10.1016/j.yfrne.2010.12.001

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