Article
Refining multivariate disease phenotypes for high chip heritability.
BMC medical genomics - 1 Jan 2015
Sun Jiangwen, Kranzler Henry R, Bi Jinbo
Abstract excerpt
BACKGROUND: Statistical genetics shows that the success of both genetic association studies and genomic prediction methods is positively associated with the heritability of the trait used in the analysis. Identifying highly heritable components of a complex disease can thus enhance genetic studies of the disease. Existing heritable component analysis methods use data from related individuals to compute...
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