Article
The validity of cocaine dependence subtypes.
Addictive behaviors - 1 Jan 2008
Kranzler Henry R, Wilcox Marsha, Weiss Roger D, Brady Kathleen, Hesselbrock Victor, Rounsaville Bruce, Farrer Lindsay, Gelernter Joel
Abstract excerpt
Cocaine dependence (CD) is a multifactorial disorder, variable in its manifestations, and heritable. We examined the concurrent validity of homogeneous subgroups of CD as phenotypes for genetic analysis. We applied data reduction methods and an empirical cluster-analytic approach to measures of cocaine use, cocaine-related effects, and cocaine treatment history in 1393 subjects, from 660 small nuclear families....
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