Article
The common equine class I molecule Eqca-1*00101 (ELA-A3.1) is characterized by narrow peptide binding and T cell epitope repertoires.
Immunogenetics - 1 Nov 2015
Bergmann Tobias, Moore Carrie, Sidney John, Miller Donald, Tallmadge Rebecca, Harman Rebecca M, Oseroff Carla, Wriston Amanda, Shabanowitz Jeffrey, Hunt Donald F, Osterrieder Nikolaus, Peters Bjoern, Antczak Douglas F, Sette Alessandro
Abstract excerpt
Here we describe a detailed quantitative peptide-binding motif for the common equine leukocyte antigen (ELA) class I allele Eqca-1*00101, present in roughly 25 % of Thoroughbred horses. We determined a preliminary binding motif by sequencing endogenously bound ligands. Subsequently, a positional scanning combinatorial library (PSCL) was used to further characterize binding specificity and derive a quantitative...
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