Article
Newly identified variability of the antigen binding site coding sequences of the equine major histocompatibility complex class I and class II genes.
HLA - 1 Oct 2023
Plasil Martin, Oppelt Jan, Klumplerova Marie, Bubenikova Jana, Vychodilova Leona, Janova Eva, Stejskalova Karla, Futas Jan, Knoll Ales, Leblond Agnes, Mihalca Andrei D, Horin Petr
Abstract excerpt
The major histocompatibility complex (MHC) with its class I and II genes plays a crucial role in the immune response to pathogens by presenting oligopeptide antigens to various immune response effector cells. In order to counteract the vast variability of infectious agents, MHC class I and II genes usually retain high levels of SNPs mainly concentrated in the exons encoding the antigen binding sites. The aim of...
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