Evidence that derivation of the adenocarcinoma LT85 predated establishment of the H-2km2 mutation in a C3Hf colony of mice.

Abstract excerpt

The adenocarcinoma LT85 was chemically induced in a mouse from a C3Hf colony shown subsequently to be inbred for a gene conversion-like mutation at the H-2K locus, characterized by a clustered four nucleotide substitution in exon 3. The H-2K phenotype of LT85, however, more closely resembles that of C3H rather than the mutant strain now designated C3Hf H-2km2. We cloned and sequenced the H-2K gene from this tumor...

Topics

• Adenocarcinoma
• Amino Acid Sequence
• Animals
• Base Sequence
• Blotting, Southern
• Cell Line
• Cloning, Molecular
• H-2 Antigens
• Mice
• Mice, Inbred C3H
• Molecular Sequence Data