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Article

Evolution of the mouse H-2K region: a hot spot of mutation associated with genes transcribed in embryos and/or germ cells.

Genetics - 1 Mar 1992

Yeom Y I, Abe K, Artzt K

Abstract excerpt

Active gene transcription is known to promote genetic change in neighboring DNA. We reasoned that the change would be readily heritable if transcription was occurring in germ cells or early embryonic cells before the germ cells are set aside. The H-2K region of the major histocompatibility complex (MHC) provides a good vehicle for testing this hypothesis because it is replete with such genes. We have compared the...

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Identifiers

PMID: 1348042
DOI: 10.1093/genetics/130.3.629
PMCID: PMC1204879

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