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Article

Seipin knockout in mice impairs stem cell proliferation and progenitor cell differentiation in the adult hippocampal dentate gyrus via reduced levels of PPARγ.

Disease models & mechanisms - 1 Dec 2015

Li Guoxi, Zhou Libin, Zhu Ying, Wang Conghui, Sha Sha, Xian Xunde, Ji Yong, Liu George, Chen Ling

Abstract excerpt

The seipin gene (BSCL2) was originally identified in humans as a loss-of-function gene associated with congenital generalized lipodystrophy type 2 (CGL2). Neuronal seipin-knockout (seipin-nKO) mice display a depression-like phenotype with a reduced level of hippocampal peroxisome proliferator-activated receptor gamma (PPARγ). The present study investigated the influence of seipin deficiency on adult neurogenesis...

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Source

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Identifiers

PMID: 26398946
DOI: 10.1242/dmm.021550
PMCID: PMC4728316

Genes

BSCL2
STAT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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