Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Menstrual blood-derived endometrial stem cells ameliorate neuroinflammation and apoptosis through JAK2/STAT3 signaling pathway in NPC1 mutant cell and mice

29 Aug 2025

Abstract excerpt

Niemann-Pick disease type C1 (NPC1) is caused by NPC1 gene mutations, resulting in Purkinje cell degeneration and death, glial cell activation, and progressive neurodegeneration. Menstrual blood-derived endometrial stem cells (MenSCs) have been explored as a promising tool for treating neurodegenerative diseases due to their wide range of sources, non-invasive nature, and regular collection methods. This study...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Lysosomal Storage Disorders Research
Share to Neurogenesis and neuroplasticity mechanisms
Share to Reproductive System and Pregnancy

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 40877976
DOI: 10.1186/s13287-025-04575-0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Menstrual blood-derived endometrial stem cells ameliorate neuroinflammation and apoptosis through JAK2/STAT3 signaling pathway in NPC1 mutant cell and micePMID 40877976Read ↗

Menstrual blood derived endometrial stem cells alleviate neuroinflammation by modulating microglia polarization in cells and rats Parkinson’s disease modelsSemantic proximity Read ↗

Genome-wide screens in accelerated human stem cell-derived neural progenitor cells identify Zika virus host factors and drivers of proliferationSemantic proximity Read ↗

Rescue of an in vitro neuron phenotype identified in Niemann-Pick disease, type C1 induced pluripotent stem cell-derived neurons by modulating the WNT pathway and calcium signaling.Semantic proximity Read ↗

Pluripotent Stem Cells for Disease Modeling and Drug Discovery in Niemann-Pick Type C1.Semantic proximity Read ↗

Human SPG11 cerebral organoids reveal cortical neurogenesis impairmentSemantic proximity Read ↗

Human umbilical cord blood-derived mesenchymal stem cells improve neurological abnormalities of Niemann-Pick type C mouse by modulation of neuroinflammatory condition.Semantic proximity Read ↗

Identification of neuron-glia signaling feedback in human schizophrenia using patient-derived, mix-and-match forebrain assembloidsSemantic proximity Read ↗

Human endometrial-derived mesenchymal stem cells suppress inflammation in the central nervous system of EAE mice.Semantic proximity Read ↗

Cerebral organoids in primary progressive multiple sclerosis reveal stem cell and oligodendrocyte differentiation defectSemantic proximity Read ↗

Betulinic Acid Exerts Cytoprotective Activity on Zika Virus-Infected Neural Progenitor CellsSemantic proximity Read ↗

NPC1 Gene Deficiency Leads to Lack of Neural Stem Cell Self-Renewal and Abnormal Differentiation Through Activation of p38 Mitogen-Activated Protein Kinase SignalingSemantic proximity Read ↗

Targeting UBE3A and downstream estrogen receptor-β signaling to restore oligodendroglial homeostasis in Angelman syndromeSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.