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Article

Association study of genetic variants in PLA2G4A, PLCG1, LAT, SYK, and TNFRS11A genes in NSAIDs-induced urticaria and/or angioedema patients.

Pharmacogenetics and genomics - 1 Dec 2015

Ayuso Pedro, Plaza-Serón María del Carmen, Doña Inmaculada, Blanca-López Natalia, Campo Paloma, Cornejo-García José A, Perkins James R, Torres Maria J, Blanca Miguel, Canto Gabriela

Abstract excerpt

NSAIDs-induced urticaria and/or angioedema (NIUA) is the most frequent entity of hypersensitivity reactions to NSAIDs. The underlying cause is considered to be because of a nonspecific immunological mechanism in which mast cells are key players. We studied the association of nine single nucleotide polymorphisms in five genes involved in mast cell activation (SYK, LAT1, PLCG1, PLA2G4A, and TNFRSF11A) in 450 NIUA...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 26398624
DOI: 10.1097/FPC.0000000000000179

Genes

PLCG1
SYK
LAT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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