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Article

Copy number variation in ALOX5 and PTGER1 is associated with NSAIDs-induced urticaria and/or angioedema.

Pharmacogenetics and genomics - 1 Jun 2016

Plaza-Serón María Del Carmen, Ayuso Pedro, Pérez-Sánchez Natalia, Doña Inmaculada, Blanca-Lopez Natalia, Flores Carlos, Galindo Luisa, Molina Ana, Perkins James R, Cornejo-García Jose A, Agúndez Jose A, García-Martín Elena, Campo Paloma, Canto Gabriela, Blanca Miguel

Abstract excerpt

OBJECTIVE: Cross-intolerance to NSAIDs is a class of drug hypersensitivity reaction, of which NSAIDs-induced urticaria and/or angioedema (NIUA) are the most frequent clinical entities. They are considered to involve dysregulation of the arachidonic acid pathway; however, this mechanism has not been confirmed for NIUA. In this work, we assessed copy number variations (CNVs) in eight of the main genes involved in...

Read the complete abstract on PubMed

Topics

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Share to Angioedema
Share to Anti-Inflammatory Agents, Non-Steroidal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Arachidonate 5-Lipoxygenase

Share to Case-Control Studies

Share to DNA Copy Number Variations

Share to ALOX5 gene

Share to Polymorphism, Single Nucleotide

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Source

Identifiers

PMID: 26959713
DOI: 10.1097/FPC.0000000000000216

Genes

ALOX5
PTGER1
PTGER3
PTGER4
PTGER2
PTGS1
PTGS2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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