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Article

CADPS functional mutations in patients with bipolar disorder increase the sensitivity to stress.

Molecular psychiatry - 1 Feb 2022

Sitbon Jérémy, Nestvogel Dennis, Kappeler Caroline, Nicolas Aude, Maciuba Stephanie, Henrion Annabelle, Troudet Réjane, Courtois Elisa, Grannec Gaël, Latapie Violaine, Barau Caroline, Le Corvoisier Philippe, Pietrancosta Nicolas, Henry Chantal, Leboyer Marion, Etain Bruno, Nosten-Bertrand Marika, Martin Thomas F J, Rhee JeongSeop, Jamain Stéphane

Abstract excerpt

Bipolar disorder is a severe and chronic psychiatric disease resulting from a combination of genetic and environmental risk factors. Here, we identified a significant higher mutation rate in a gene encoding the calcium-dependent activator protein for secretion (CADPS) in 132 individuals with bipolar disorder, when compared to 184 unaffected controls or to 21,070 non-psychiatric and non-Finnish European subjects...

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Identifiers

PMID: 35169262
DOI: 10.1038/s41380-021-01151-9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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