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Article

Eyeing the Cyr61/CTGF/NOV (CCN) group of genes in development and diseases: highlights of their structural likenesses and functional dissimilarities.

Human genomics - 23 Sept 2015

Krupska Izabela, Bruford Elspeth A, Chaqour Brahim

Abstract excerpt

"CCN" is an acronym referring to the first letter of each of the first three members of this original group of mammalian functionally and phylogenetically distinct extracellular matrix (ECM) proteins [i.e., cysteine-rich 61 (CYR61), connective tissue growth factor (CTGF), and nephroblastoma-overexpressed (NOV)]. Although "CCN" genes are unlikely to have arisen from a common ancestral gene, their encoded proteins...

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Source

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Identifiers

PMID: 26395334
DOI: 10.1186/s40246-015-0046-y
PMCID: PMC4579636

Genes

CCN1
CCN3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Eyeing the Cyr61/CTGF/NOV (CCN) group of genes in development and diseases: highlights of their structural likenesses and functional dissimilarities.PMID 26395334Read ↗

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Decreased expression of the angiogenic regulators CYR61 (CCN1) and NOV (CCN3) in human placenta is associatedwith pre-eclampsiaSemantic proximity Read ↗

Analysis of CCN6 in the Context of Human Health and Disease: Current Insights and Unexplored Frontiers.Semantic proximity Read ↗

The matricellular protein CCN1 is essential for cardiac development.Semantic proximity Read ↗

The Matricellular Protein Cysteine-rich Protein 61 (CCN1/Cyr61) Enhances Physiological Adaptation of Retinal Vessels and Reduces Pathological Neovascularization Associated with Ischemic RetinopathySemantic proximity Read ↗

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