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Article

Endogenous CCN family member WISP1 inhibits trauma-induced heterotopic ossification

2 Jun 2020

Abstract excerpt

Heterotopic ossification (HO) is defined as abnormal differentiation of local stromal cells of mesenchymal origin, resulting in pathologic cartilage and bone matrix deposition. Cyr61, CTGF, Nov (CCN) family members are matricellular proteins that have diverse regulatory functions on cell proliferation and differentiation, including the regulation of chondrogenesis. However, little is known regarding CCN family...

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PMID: 32484792
DOI: 10.1172/jci.insight.135432

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