Altered Protamine 2 Expression Is Uncommon In Donors of Known Fertility, but Common Among Men With Poor Fertilizing Capacity, and May Reflect Other Abnormalities of Spermiogenesis

Abstract excerpt

During the spermatid elongation stage of spermiogenesis approximately 85% of sperm nuclear histones are replaced by protamines. Protamines increase the packing ratio of sperm chromatin, presumably facilitating sperm motility and function. In this study we evaluated the incidence of abnormal protamine expression in 75 patients undergoing in vitro fertilization (IVF) and 50 donors of known fertility by isolation of...

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