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Article

IFNβ impairs extracellular matrix formation leading to inhibition of mineralization by effects in the early stage of human osteoblast differentiation.

Journal of cellular physiology - 1 Jun 2012

Woeckel V J, Eijken M, van de Peppel J, Chiba H, van der Eerden B C J, van Leeuwen J P T M

Abstract excerpt

Osteoimmunology is an emerging field of research focused on the interaction of the immune system and bone. In this study we demonstrate that human osteoblasts are sensitive to the immune cytokine interferon (IFN)β. Osteoblasts respond to IFNβ as shown by the induction of several known IFN target genes such as interferon-induced (IFI) proteins (IFIT1, IFI44L), interferon-stimulated gene factor 3 (ISGF3) complex...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 21898404
DOI: 10.1002/jcp.23009

Genes

ANXA2
FBLN1
FBN2
HAS1
LAMA1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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