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Transcriptional Regulation of Osteoblasts

27 Aug 2008

Abstract excerpt

The differentiation of osteoblasts from mesenchymal precursors requires a series of cell fate decisions controlled by a hierarchy of transcription factors. These include RUNX2, Osterix (OSX), ATF4 and a large number of nuclear coregulators. During bone development, initial RUNX2 expression coincides with the formation of mesenchymal condensations and precedes the branching of chondrogenic and osteogenic lineages....

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PMID: 18728356
DOI: 10.1159/000151747

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