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Article

IFNγ-dependent, spontaneous development of colorectal carcinomas in SOCS1-deficient mice

22 May 2006

Abstract excerpt

Approximately 20% of human cancers are estimated to develop from chronic inflammation. Recently, the NF-kappaB pathway was shown to play an essential role in promoting inflammation-associated cancer, but the role of the JAK/STAT pathway, another important signaling pathway of proinflammatory cytokines, remains to be investigated. Suppressor of cytokine signaling-1 (SOCS1) acts as an important physiological...

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PMID: 16717119
DOI: 10.1084/jem.20060436

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