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Article

A monoallelic-to-biallelic T-cell transcriptional switch regulates GATA3 abundance.

Genes & development - 15 Sept 2015

Ku Chia-Jui, Lim Kim-Chew, Kalantry Sundeep, Maillard Ivan, Engel James Douglas, Hosoya Tomonori

Abstract excerpt

Protein abundance must be precisely regulated throughout life, and nowhere is the stringency of this requirement more evident than during T-cell development: A twofold increase in the abundance of transcription factor GATA3 results in thymic lymphoma, while reduced GATA3 leads to diminished T-cell production. GATA3 haploinsufficiency also causes human HDR (hypoparathyroidism, deafness, and renal dysplasia)...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26385963
DOI: 10.1101/gad.265025.115
PMCID: PMC4579350

Genes

GATA3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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