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Article

Genotype-dependent cooperation of ionizing radiation with BRAF inhibition in BRAF V600E-mutated carcinomas.

Investigational new drugs - 1 Oct 2013

Dasgupta Tina, Haas-Kogan Daphne A, Yang Xiaodong, Olow Aleksandra, Yang Daniel X, Gragg Ashley, Orloff Lisa A, Yom Sue S

Abstract excerpt

BACKGROUND: A substantial proportion of solid tumors carry the BRAF V600E mutation, which causes activation of the MEK/MAPK pathway and is a poor prognostic indicator. Patients with locally advanced human cancers are often treated with external beam radiation therapy. Given the association of Raf...

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Source

Identifiers

PMID: 23354848
DOI: 10.1007/s10637-013-9928-9

Genes

BRAF

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23354848-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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