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Article

Dual inhibition of MAPK and TORC1 signaling retards development of radiation resistance in pediatric BRAFV600E glioma models.

Neuro-oncology - 8 Sept 2025

Li Fuyang, Bondra Kathryn M, Wang Hanzhou, Kurmashev Dias, Mukherjee Bipasha, Kanji Suman, Habib Amyn A, Chen Yidong, Zheng Siyuan, Burma Sandeep, Houghton Peter J

Abstract excerpt

BACKGROUND: MAPK pathway inhibitors (MAPKi) have shown significant efficacy in treating childhood BRAF-activated brain tumors. For tumors harboring BRAFV600E mutations, the drugs are rarely curative, and patients can become refractory to treatment. MAPKi combining X-radiation therapy (XRT) may improve cure rate, but the development of XRT resistance is a challenge. METHODS: XRT resistance was induced by multiple...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40083135
DOI: 10.1093/neuonc/noaf068
PMCID: PMC12417835

Genes

BRAF
TSC2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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