Article

Radiosensitization of Glioblastoma by the K-ras Inhibitor RMC-6236

2026-06-02

Abstract excerpt

<h4>Purpose</h4> Glioblastoma (GBM) is characterized by poor clinical outcomes and marked resistance to radiotherapy. Because effective radiosensitizing strategies for GBM remain limited, we investigated whether inhibition of KRAS/RAS signaling could enhance radiation response in GBM. In particular, we evaluated the radiosensitizing potential of RMC-6236, an RAS(ON) multiselective inhibitor that suppresses active...

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Literature Corpus work: 744534f3-6521-5dc7-9657-5eb4c13c4c22
DOI: 10.64898/2026.05.29.728724

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